Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NEK4 | P51957 | 1/20 | 0.51 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.51 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.51 |
| ▸ | MERTK | Q12866 | 1/20 | 0.51 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870385 | 0.87 | RIPK1 (0.48) | RIPK1EIF2AK3MEN1KMT2ANOTUM | |
| SCHEMBL24491357 | 0.86 | RIPK1 (0.61) | RIPK1NTRK1LCKYES1RET | |
| SCHEMBL30876862 | 0.86 | RIPK1 (0.61) | RIPK1NTRK1LCKYES1RET | |
| SCHEMBL30301910 | 0.86 | ALDH1A1 (0.57) | LCKEIF2AK2AURKBEIF2AK1EIF2AK3 | |
| SCHEMBL19098411 | 0.86 | ALDH1A1 (0.57) | LCKEIF2AK2AURKBEIF2AK1EIF2AK3 | |
| SCHEMBL869066 | 0.79 | RIPK1 (0.55) | RIPK1NTRK1CYP1A2LCKYES1 | |
| SCHEMBL29995958 | 0.79 | CYP11B1 (0.51) | ALDH1A1LMNAMAPTCYP11B1CYP11B2 | |
| SCHEMBL23063812 | 0.79 | CYP11B1 (0.51) | ALDH1A1LMNAMAPTCYP11B1CYP11B2 | |
| SCHEMBL2084507 | 0.78 | CA12 (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19NOTUM | |
| SCHEMBL868522 | 0.76 | ROCK1 (0.50) | CYP3A4EIF2AK3MEN1KMT2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | RIPK1 218/4885NTRK1 2297/4885CYP1A2 1446/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | RIPK1 218/4885NTRK1 2297/4885CYP1A2 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.