Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 6/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15748138 | 0.85 | DRD2 (0.68) | DRD4DRD3DRD2HTR1AGAA | |
| SCHEMBL8686589 | 0.84 | MAPT (0.54) | DRD4DRD3DRD2LMNAHTR1A | |
| SCHEMBL7575294 | 0.79 | DRD4 (0.50) | DRD4DRD3DRD2LMNAHTR1A | |
| SCHEMBL7052509 | 0.77 | CDK4 (0.57) | LMNAKMT2AHTR2A | |
| SCHEMBL4828100 | 0.77 | CDK4 (0.57) | LMNAKMT2AHTR2A | |
| SCHEMBL5944315 | 0.76 | CDK4 (0.52) | DRD4DRD3DRD2LMNASMN1; SMN2 | |
| SCHEMBL3205345 | 0.76 | CDK4 (0.56) | DRD4DRD3DRD2SIGMAR1HTR2A | |
| SCHEMBL8629425 | 0.76 | DRD4 (0.56) | DRD4DRD3DRD2LMNAHTR1A | |
| SCHEMBL4896448 | 0.76 | CDK4 (0.55) | LMNASMN1; SMN2KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL28867138 | 0.75 | CDK4 (0.55) | DRD4DRD3DRD2SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814644-A | Indole derivatives as dopamine D4 antagonists | MERCK SHARP & DOHME, LTD. (GB) | 1998-09-29 | — | — | US | disclosed |