Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.56 |
| ▸ | DRD3 | P35462 | 12/20 | 0.56 |
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633681 | 0.89 | RECQL (0.50) | DRD4DRD3DRD2HTR1AADRA1D | |
| SCHEMBL8629124 | 0.87 | DRD4 (0.48) | DRD4DRD3DRD2HTR1AADRA1D | |
| SCHEMBL8631570 | 0.87 | MAPT (0.47) | DRD4DRD3DRD2HTR1ALMNA | |
| SCHEMBL8630582 | 0.84 | MAPT (0.54) | DRD4DRD2HTR1ALMNASMN1; SMN2 | |
| SCHEMBL8630532 | 0.84 | DRD2 (0.46) | DRD4DRD3DRD2HTR1APOLB | |
| SCHEMBL8627881 | 0.83 | MAPT (0.50) | DRD4DRD3DRD2HTR1ADRD1 | |
| SCHEMBL8633899 | 0.82 | KMT2A (0.50) | ADRA1DADRA1AADRA1BSMN1; SMN2POLB | |
| SCHEMBL8631540 | 0.79 | KCNH2 (0.51) | DRD4DRD3DRD2HTR1APOLB | |
| SCHEMBL8627836 | 0.78 | DRD4 (0.45) | DRD4DRD3DRD2HTR1ALMNA | |
| SCHEMBL29520874 | 0.78 | RECQL (0.53) | SMN1; SMN2POLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |