Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.57 |
| ▸ | PDE5A | O76074 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8793521 | 0.82 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8465685 | 0.81 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL7375824 | 0.79 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8206531 | 0.79 | PDE4A (0.80) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL27364966 | 0.79 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8684350 | 0.78 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8465687 | 0.78 | PDE4A (0.68) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8483493 | 0.78 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8683889 | 0.78 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8461881 | 0.77 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |