Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465685 | 0.90 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8465687 | 0.87 | PDE4A (0.68) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8461881 | 0.84 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL5823060 | 0.81 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL8466183 | 0.81 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL8206531 | 0.81 | PDE4A (0.80) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL4600365 | 0.80 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL8684271 | 0.79 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8466031 | 0.79 | PDE4A (0.75) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL5309884 | 0.78 | PDE4D (0.67) | PDE4APDE4DPDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995027692-A1 | SUBTITUTED BIPHENYL TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-19 | — | — | WO | disclosed |