Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28870890 | 0.81 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL28870892 | 0.76 | HIF1A (0.48) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6864582 | 0.76 | PDE4D (0.58) | PDE5APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8394725 | 0.75 | CNR2 (0.42) | — | |
| SCHEMBL27529700 | 0.75 | MAPT (0.48) | — | |
| SCHEMBL17397335 | 0.73 | POLB (0.55) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7417740 | 0.73 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL8684350 | 0.72 | PDE4A (0.53) | PDE5APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL27521810 | 0.72 | PDE4A (0.60) | PDE5APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3363106 | 0.71 | MEN1 (0.48) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |