SCHEMBL8685

SCHEMBL8685

FC(F)(F)Oc1c[c]ccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 3/20 0.34
MAPT P10636 4/20 0.33
KIF11 P52732 3/20 0.33
EPHX2 P34913 1/20 0.33
NOTUM Q6P988 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
CYP3A4 P08684 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
BLM P54132 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HIF1A Q16665 1/20 0.32
HSD17B10 Q99714 1/20 0.32
EPAS1 Q99814 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CETP P11597 1/20 0.31
CHRM2 P08172 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28046395 0.98 GPR3 (0.33) GPR3MAPTKIF11EPHX2NOTUM
SCHEMBL921822 0.87 EPHX2 (0.39) GPR3MAPTEPHX2MEN1KMT2A
SCHEMBL8615049 0.85
SCHEMBL922225 0.84 CETP (0.39) GPR3MAPTKIF11NOTUMMEN1
SCHEMBL17134180 0.83
SCHEMBL17133938 0.83
SCHEMBL7159968 0.83 ALDH1A1 (0.31) ALDH1A1
SCHEMBL9531099 0.83
SCHEMBL2091148 0.83
SCHEMBL8611645 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4997 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117143099-B Evodiamine derivative, preparation method thereof and application of evodiamine derivative as PGAM1 inhibitor 陕西中医药大学 2024-07-09 CN claimed
CN-118281333-A Electrolyte additive, nonaqueous electrolyte and application thereof 深圳市研一新材料有限责任公司 2024-07-02 CN claimed
CN-118265702-A Microbiocidal isonicotinamide derivatives 先正达农作物保护股份公司 2024-06-28 CN claimed
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-06-27 US claimed
EP-3849664-B1 PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2024-06-12 EP claimed
WO-2024115549-A1 ARYL- AND HETEROARYL-SULFONAMIDE DERIVATIVES AS CCR8 MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2024-06-06 WO claimed
WO-2024118801-A1 LINEAR HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS PROTEGO BIOPHARMA, INC. (US) 2024-06-06 WO claimed
CN-118108698-A Beta-carbonyl sulfinolactone compound and preparation method thereof 华中师范大学 2024-05-31 CN claimed
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US claimed
EP-4146643-B1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2024-05-29 EP claimed
WO-1993024600-A1 OXIDATION-RESISTANT CYCLOPHOSPHAZENE FLUID INCLUDING TRIARYLPHOSPHINE OR PHOSPHINE OXIDE THE DOW CHEMICAL COMPANY (US) 1993-12-09 WO claimed
US-5266552-A Biological antigrowth agents for plants IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-11-30 US claimed
US-5247076-A IMIDAZOLIDYL MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY MERCK & CO., INC. (US) 1993-09-21 US claimed
WO-1993008183-A1 2-(2-BENZO(b)THIENYL)-3-METHOXYACRYLATE AND -2-IMINOACETATE DERIVATIVES TO BE USED AS PESTICIDES CIBA-GEIGY AG (CH) 1993-04-29 WO claimed
EP-0536896-A1 Imidazolidyl macrolides having immunosuppressive activity MERCK & CO. INC. (US) 1993-04-14 EP claimed
WO-1993005059-A1 IMIDAZOLIDYL MACROLIDES MERCK & CO., INC. (US) 1993-03-18 WO claimed
US-5194652-A High temperature lubricants, hydraulic fluids; jet aircraft, turbines, diesel engines THE DOW CHEMICAL COMPANY (US) 1993-03-16 US claimed
US-4960768-A Acyloxythiophene-carboxamide fungicides BAYER AKTIENGESELLSCHAFT (DE) 1990-10-02 US claimed
US-4863954-A Acyloxythiophene-carboxamide fungicides BAYER AKTIENGESELLSCHAFT (DE) 1989-09-05 US claimed
EP-0241735-A2 Acyloxythiophene carbon amide BAYER AG (DE) 1987-10-21 EP claimed