Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.63 |
| ▸ | MMP9 | P14780 | 9/20 | 0.63 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191062 | 1.00 | MMP2 (0.63) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL7358058 | 0.90 | MMP2 (0.56) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL6268763 | 0.90 | MMP2 (0.56) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL713304 | 0.87 | MMP9 (0.61) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL698079 | 0.87 | MMP9 (0.61) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL698080 | 0.87 | MMP9 (0.61) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL5189409 | 0.86 | TDP1 (0.60) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL11946620 | 0.86 | MMP2 (0.56) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL10967894 | 0.86 | TDP1 (0.60) | MMP2MMP9ADAMTS4MMP13MMP8 | |
| SCHEMBL4041026 | 0.86 | TDP1 (0.60) | MMP2MMP9ADAMTS4MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |