Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GGT1 | P19440 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27134697 | 0.84 | STS (0.64) | KDM4EALDH1A1HPGDHSD17B10CA1 | |
| Hydrazine SCHEMBL9315732 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10HMGB1 | |
| SCHEMBL27132922 | 0.83 | STS (0.51) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL26647 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10HMGB1 | |
| SCHEMBL27029727 | 0.82 | STS (0.62) | KDM4EALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL27029738 | 0.81 | STS (0.50) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL8769958 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10HMGB1 | |
| SCHEMBL291628 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10HMGB1 | |
| Ammonia Solution, Strong SCHEMBL10686252 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10HMGB1 | |
| SCHEMBL19122203 | 0.81 | ELANE (0.53) | KDM4EALDH1A1HPGDHSD17B10HMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077711-A1 | Novel Ligands and Libraries of Ligands | SUNESIS PHARMACEUTICALS, INC. (US) | 2012-03-29 | — | — | US | disclosed |
| EP-1939625-A2 | Methods for ligand discovery | Sunesis Pharmaceuticals, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| US-6998233-B2 | Methods for ligand discovery | SUNESIS PHARMACEUTICALS, INC. (US) | 2006-02-14 | — | — | US | disclosed |
| US-20050287596-A9 | Novel ligands and libraries of ligands | SUNESIS PHARMACEUTICALS, INC. | 2005-12-29 | — | — | US | disclosed |
| US-20050142614-A1 | Methods for ligand discovery | WELLS JIM (US) | 2005-06-30 | — | — | US | disclosed |
| EP-1446496-A4 | METHODS FOR LIGAND DISCOVERY | SUNESIS PHARMACEUTICALS INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1446496-A2 | METHODS FOR LIGAND DICOVERY | Sunesis Pharmaceuticals, Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-1421063-A1 | DISULFIDE AND THIOSULFONATE LIGANDS AND LIBRARIES COMPRISING THESE LIGANDS | Sunesis Pharmaceuticals, Inc. (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20040043426-A1 | Methods for ligand discovery | WELLS JIM (US) | 2004-03-04 | — | — | US | disclosed |
| WO-2003046200-A2 | METHODS FOR LIGAND DISCOVERY | SUNESIS PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |
| WO-2003014072-A1 | DISULFIDE AND THIOSULFONATE LIGANDS AND LIBRARIES COMPRISING THESE LIGANDS | SUNESIS PHARMACEUTICALS, INC. (US) | 2003-02-20 | — | — | WO | disclosed |
| US-20030013125-A1 | Novel ligands and libraries of ligands | BRAISTED ANDREW C (US) | 2003-01-16 | — | — | US | disclosed |
| US-20020155505-A1 | Methods for ligand discovery | SUNESIS PHARMACEUTICALS, INC. | 2002-10-24 | — | — | US | disclosed |
| US-5273993-A | Antiarthritic agents; osteoporosis | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-12-28 | — | — | US | disclosed |
| US-5194446-A | Antiarthritic agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-16 | — | — | US | disclosed |
| US-5025031-A | Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants | A. H. ROBINS CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0403185-A2 | Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043426-A1 | Methods for ligand discovery | ADGRF1, VCAM1, LDLR | KDM4E 3156/4885ALDH1A1 1677/4885HPGD 2782/4885 |
| US-20020155505-A1 | Methods for ligand discovery | ADGRF1, VCAM1, LDLR | KDM4E 3156/4885ALDH1A1 1677/4885HPGD 2782/4885 |
| US-20050287596-A9 | Novel ligands and libraries of ligands | LSS, ABCG2, SELL | KDM4E 4640/4885ALDH1A1 533/4885HPGD 2879/4885 |
| US-20120077711-A1 | Novel Ligands and Libraries of Ligands | LSS, ABCG2, SELL | KDM4E 4640/4885ALDH1A1 533/4885HPGD 2879/4885 |
| US-20030013125-A1 | Novel ligands and libraries of ligands | LSS, ABCG2, SELL | KDM4E 4734/4885ALDH1A1 400/4885HPGD 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.