Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446551 | 1.00 | NOTUM (0.69) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL3102790 | 0.90 | NOTUM (0.62) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL28693772 | 0.89 | NOTUM (0.54) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL5068337 | 0.89 | NOTUM (0.67) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL870500 | 0.84 | ALDH1A1 (0.70) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL21776847 | 0.84 | NOTUM (0.65) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL6648532 | 0.84 | KDM4E (0.58) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL5780390 | 0.84 | ALDH1A1 (0.70) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL8813833 | 0.83 | NOTUM (0.60) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL4523697 | 0.83 | NOTUM (0.60) | NOTUMALDH1A1HPGDKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114213310-B | Indoline compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2024-02-23 | — | — | CN | disclosed |
| WO-2023125473-A1 | INDOLINE COMPOUNDS AND DERIVATIVES THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国药科大学 | 2023-07-06 | — | — | WO | disclosed |
| CN-114213310-A | Indoline compound and derivative, preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2022-03-22 | — | — | CN | disclosed |
| US-9394251-B2 | Silodosin intermediate and preparation method therefor | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2016-07-19 | — | — | US | disclosed |
| US-20150148548-A1 | Silodosin Intermediate and Preparation Method Therefor | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. | 2015-05-28 | — | — | US | disclosed |
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| CN-102917588-B | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-08 | — | — | CN | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| CN-102917588-A | Chemical compounds | GLAXOSMITHKLINE LLC | 2013-02-06 | — | — | CN | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| EP-1161418-B1 | 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS | MEDICAL RES COUNCIL (GB) | 2005-12-28 | — | — | EP | disclosed |
| US-6765014-B1 | DRUG DELIVERY OF NEUROACTIVE AMINO ACIDS OR METAL CHELATORS | MEDICAL RESEARCH COUNCIL (GB) | 2004-07-20 | — | — | US | disclosed |
| EP-1161418-A1 | 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS | MEDICAL RESEARCH COUNCIL (GB) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055133-A1 | 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS | MEDICAL RESEARCH COUNCIL (GB) | 2000-09-21 | — | — | WO | disclosed |
| US-4650810-A | OR INDOLE-5-THIOACETAMIDES | GLAXO GROUP LIMITED (GB) | 1987-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | NOTUM 2790/4885ALDH1A1 1192/4885HPGD 2743/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | NOTUM 2790/4885ALDH1A1 1192/4885HPGD 2743/4885 |
| US-20150148548-A1 | Silodosin Intermediate and Preparation Method Therefor | CYP51A1, VIP, CYP4F11 | NOTUM 128/4885ALDH1A1 539/4885HPGD 62/4885 |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | NOTUM 2558/4885ALDH1A1 3985/4885HPGD 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.