Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 12/20 | 0.59 |
| ▸ | HTR1D | P28221 | 10/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | NOS3 | P29474 | 2/20 | 0.56 |
| ▸ | NOS1 | P29475 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686525 | 0.79 | HTR1B (0.67) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8688634 | 0.79 | HTR1B (0.67) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8688640 | 0.79 | HTR1B (0.67) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8790804 | 0.78 | HTR1B (0.72) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8790809 | 0.78 | HTR1B (0.72) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8979695 | 0.78 | HTR6 (0.38) | HTR1BHTR1DNOS3NOS1HTR6 | |
| SCHEMBL8914362 | 0.77 | HTR1B (0.69) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8790703 | 0.77 | HTR1B (0.70) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8790698 | 0.77 | HTR1B (0.70) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8686140 | 0.76 | HTR1B (0.65) | HTR1BHTR1DHTR1ANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770742-A | SEROTONIN RECEPTOR SELECTIVITY, MIGRAINES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-23 | — | — | US | disclosed |
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |