Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29715187 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL31447779 | 0.86 | TDP1 (0.52) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL8686354 | 0.86 | TDP1 (0.52) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL27286335 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL29450699 | 0.81 | MEN1 (0.65) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL29903883 | 0.81 | MEN1 (0.65) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL8623371 | 0.81 | MEN1 (0.65) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL187061 | 0.80 | ALDH1A1 (0.63) | ALDH1A1TDP1TSHRLMNAMEN1 | |
| SCHEMBL4958995 | 0.79 | TSHR (0.52) | ALDH1A1TSHRLMNAGAATHRB | |
| SCHEMBL9719317 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1CYP3A4TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12590105-B2 | KRas G12C inhibitors | ELI LILLY AND COMPANY (US) | 2026-03-31 | — | — | US | disclosed |
| US-20240025916-A1 | KRAS G12C INHIBITORS | ELI LILLY AND COMPANY | 2024-01-25 | — | — | US | disclosed |
| CN-116528868-A | Tricyclic KRAS G12C inhibitors | 伊莱利利公司 | 2023-08-01 | — | — | CN | disclosed |
| EP-2415756-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
| US-5811492-A | HAVING EXCELLENT HEAT, FIRE, CHEMICAL AND IMPACT RESISTANCE, MECHANICAL STRENGTH, AND MOLDABILITY; CONTAINING AMINO GROUPS, HYDROGENATED BLOCK COPOLYMER AND A POLYAMIDE RESIN | GENERAL ELECTRIC COMPANY (US) | 1998-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025916-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | ALDH1A1 2669/4885TDP1 3107/4885CYP3A4 4113/4885 |
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | BACE1, BACE2, APP | ALDH1A1 1013/4885TDP1 945/4885CYP3A4 1245/4885 |
| US-12590105-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | ALDH1A1 2890/4885TDP1 3561/4885CYP3A4 2429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.