Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719324 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TSHRTDP1CYP1A2CYP2A6 | |
| SCHEMBL8623371 | 0.81 | MEN1 (0.65) | ALDH1A1TSHRTDP1CYP2A6HSD17B10 | |
| SCHEMBL29903883 | 0.81 | MEN1 (0.65) | ALDH1A1TSHRTDP1CYP2A6HSD17B10 | |
| SCHEMBL29450699 | 0.81 | MEN1 (0.65) | ALDH1A1TSHRTDP1CYP2A6HSD17B10 | |
| SCHEMBL187061 | 0.80 | ALDH1A1 (0.63) | ALDH1A1TSHRTDP1HPGDACHE | |
| SCHEMBL29715187 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TSHRTDP1HPGDHSD17B10 | |
| SCHEMBL27054914 | 0.79 | TSHR (0.50) | ALDH1A1TSHRTDP1CYP1A2ACHE | |
| SCHEMBL8686458 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TSHRTDP1HPGDHSD17B10 | |
| SCHEMBL4958995 | 0.79 | TSHR (0.52) | ALDH1A1TSHRHPGDLMNANPC1 | |
| SCHEMBL29715190 | 0.79 | TSHR (0.50) | ALDH1A1TSHRTDP1CYP1A2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025916-A1 | KRAS G12C INHIBITORS | ELI LILLY AND COMPANY | 2024-01-25 | — | — | US | disclosed |
| WO-2022119748-A1 | TRICYCLIC KRAS G12C INHIBITORS | ELI LILLY AND COMPANY (US) | 2022-06-09 | — | — | WO | disclosed |
| US-20170267689-A1 | STIMULI-SWITCHABLE MOIETIES, MONOMERS AND POLYMERS INCORPORATING STIMULI-SWITCHABLE MOIETIES, AND METHODS OF MAKING AND USING SAME | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2017-09-21 | — | — | US | disclosed |
| US-20170267689-A1 | STIMULI-SWITCHABLE MOIETIES, MONOMERS AND POLYMERS INCORPORATING STIMULI-SWITCHABLE MOIETIES, AND METHODS OF MAKING AND USING SAME | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2017-09-21 | — | — | US | disclosed |
| WO-2016029307-A1 | STIMULI-SWITCHABLE MOIETIES, MONOMERS AND POLYMERS INCORPORATING STIMULI-SWITCHABLE MOIETIES, AND METHODS OF MAKING AND USING SAME | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2016-03-03 | — | — | WO | disclosed |
| US-5138098-A | Catalytic actlation using complexing agent | AMOCO CORPORATION (US) | 1992-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025916-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | ALDH1A1 2669/4885TSHR 1542/4885TDP1 3107/4885 |
| US-20170267689-A1 | STIMULI-SWITCHABLE MOIETIES, MONOMERS AND POLYMERS INCORPORATING STIMULI-SWITCHABLE MOIETIES, AND METHODS OF MAKING AND USING SAME | PASK, PAM, PTMS | ALDH1A1 4606/4885TSHR 1350/4885TDP1 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.