Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.66 |
| ▸ | HTR1B | P28222 | 10/20 | 0.66 |
| ▸ | ICMT | O60725 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL8687845 | 0.86 | HTR1D (0.67) | HTR1DHTR1BICMTPTPN1HTR1A | |
| SCHEMBL8686553 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2CMTNR1B | |
| Dimethylamine SCHEMBL8688692 | 0.79 | HTR1D (0.67) | HTR1DHTR1BGPR84 | |
| Dimethylamine SCHEMBL8686112 | 0.75 | HTR1D (0.65) | HTR1DHTR1BICMTHTR1AABL1 | |
| Diethylamine SCHEMBL8903599 | 0.72 | HTR1D (0.64) | HTR1DHTR1B | |
| SCHEMBL532235 | 0.72 | HTR1D (0.52) | HTR1DHTR1BNPC1RAB9A | |
| Dimethylamine SCHEMBL8878578 | 0.71 | HTR2C (0.68) | HTR1DHTR1BHTR1AHTR2CCYP3A4 | |
| SCHEMBL25493845 | 0.71 | NR4A2 (0.55) | ICMT | |
| Dimethylamine SCHEMBL7871287 | 0.71 | HPGD (0.57) | HTR1DHTR1BHTR1AHTR2CCYP3A4 | |
| SCHEMBL7651463 | 0.70 | HTR1D (0.67) | HTR1DHTR1BICMTHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770742-A | SEROTONIN RECEPTOR SELECTIVITY, MIGRAINES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-23 | — | — | US | claimed |
| WO-1997043281-A1 | THIOPHENE- AND FURAN-TRYPTAMINE DERIVATIVES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-11-20 | — | — | WO | claimed |
| US-5770742-A | SEROTONIN RECEPTOR SELECTIVITY, MIGRAINES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-23 | — | — | US | disclosed |