Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689520 | 0.81 | POLB (0.35) | POLBMAPTL3MBTL1PPARGMAPK1 | |
| SCHEMBL8686882 | 0.78 | ALDH1A1 (0.37) | POLBMAPTPPARGHTTALDH1A1 | |
| SCHEMBL3774754 | 0.77 | MAPT (0.50) | POLBMAPTALDH1A1THRBGAA | |
| SCHEMBL6032173 | 0.76 | MAPT (0.54) | POLBMAPTL3MBTL1ALDH1A1THRB | |
| SCHEMBL8689646 | 0.74 | POLB (0.40) | POLBMAPTL3MBTL1PPARGLMNA | |
| SCHEMBL8687292 | 0.74 | TAAR1 (0.41) | POLBMAPTLMNAMAPK1HTT | |
| SCHEMBL7469304 | 0.73 | POLB (0.55) | POLBMAPTL3MBTL1ALDH1A1THRB | |
| SCHEMBL8689551 | 0.73 | POLB (0.41) | POLBMAPTL3MBTL1LMNAMAPK1 | |
| SCHEMBL8523889 | 0.73 | POLB (0.47) | POLBMAPTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL8687360 | 0.72 | PPARG (0.48) | MAPTL3MBTL1PPARGLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780490-A | A O-(2,4-OXA(OR THIA)ZOLIDINYL)PHENYLOXY(OR THIO OR AMINO) ALKYLOXIME; ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AND -HYPOGLYCEMIC AGENTS; LIVER, SKIN AND UROGENITAL DISORDERS | SANKYO COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5703096-A | ANTIDIABETIC AGENTS; ALDOSE REDUCTASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |