Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 15/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784303 | 0.87 | ITGB3 (0.44) | ITGB3ITGA2BALOX15F2PRSS1 | |
| Trifluoroacetic Acid SCHEMBL8784298 | 0.86 | ITGB3 (0.54) | ITGB3ITGA2BALOX15F2PRSS1 | |
| SCHEMBL8686539 | 0.85 | CHRM4 (0.39) | GPR119MEN1 | |
| Hydrochloric Acid SCHEMBL8686467 | 0.83 | ALOX15 (0.50) | ITGB3ITGA2BALOX15F2PRSS1 | |
| SCHEMBL7345347 | 0.80 | ITGB3 (0.71) | ITGB3ITGA2BALOX15GPR119F2 | |
| Hydrochloric Acid SCHEMBL8783744 | 0.79 | ALOX15 (0.66) | ITGB3ITGA2BALOX15F2PRSS1 | |
| Hydrochloric Acid SCHEMBL8686987 | 0.78 | ALOX15 (0.48) | ITGB3ITGA2BALOX15F2PRSS1 | |
| SCHEMBL8686522 | 0.78 | CHRM4 (0.38) | GPR119MEN1 | |
| Hydrochloric Acid SCHEMBL8686726 | 0.76 | ALOX15 (0.52) | ITGB3ITGA2BALOX15F2PRSS1 | |
| Hydrochloric Acid SCHEMBL8687049 | 0.76 | ALOX15 (0.52) | ITGB3ITGA2BALOX15F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773442-A | EXHIBIT GPIIB/IIIA RECEPTOR ANTAGONISTIC ACTIVITY; USEFUL FOR THE TREATMENT AND PROPHYLAXIS OF VASCULAR SYSTEM DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0810215-A1 | NOVEL BENZAMIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-12-03 | — | — | EP | disclosed |