Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 10/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.63 |
| ▸ | HTR3B | O95264 | 1/20 | 0.63 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.63 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.63 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29406314 | 1.00 | HTR3A (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8717814 | 0.90 | HTR3A (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8717812 | 0.90 | HTR3A (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8720701 | 0.88 | CNR2 (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8720700 | 0.88 | CNR2 (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8722687 | 0.87 | CNR2 (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8722683 | 0.87 | CNR2 (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8718167 | 0.85 | HTR4 (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8718168 | 0.85 | HTR4 (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8509996 | 0.84 | CNR2 (0.60) | CNR2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712408-B1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | DOMPE SPA (IT) | 1998-10-28 | — | — | EP | claimed |
| EP-0712408-A1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | Dompé S.P.A. (IT) | 1996-05-22 | — | — | EP | claimed |
| WO-1995004742-A1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | DOMPE'SPA (IT) | 1995-02-16 | — | — | WO | claimed |
| EP-0712408-B1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | DOMPE SPA (IT) | 1998-10-28 | — | — | EP | disclosed |
| US-5750536-A | ANTI-ASTHMATICS, TREATMENT OF PAIN SENSITIVITY | DOMPE ' SPA (IT) | 1998-05-12 | — | — | US | disclosed |
| EP-0712408-A1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | Dompé S.P.A. (IT) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004742-A1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | DOMPE'SPA (IT) | 1995-02-16 | — | — | WO | disclosed |