Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5612800 | 0.84 | RAB9A (0.49) | MAPTSMN1; SMN2RAB9AL3MBTL1CASP3 | |
| SCHEMBL21274654 | 0.80 | TAAR1 (0.49) | SIGMAR1MAPTCYP1A2LMNASMN1; SMN2 | |
| SCHEMBL8689397 | 0.80 | SIGMAR1 (0.53) | SIGMAR1HRH4HRH3S1PR2S1PR1 | |
| SCHEMBL8688775 | 0.76 | SIGMAR1 (0.46) | SIGMAR1CYP2D6SLC2A1 | |
| SCHEMBL5613119 | 0.74 | TP53 (0.49) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28732240 | 0.73 | TP53 (0.47) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8687024 | 0.73 | MTOR (0.42) | MAPTCYP2D6SMN1; SMN2 | |
| SCHEMBL21274684 | 0.72 | TP53 (0.43) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL4724249 | 0.72 | CYP19A1 (0.56) | MAPTCYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL21274673 | 0.71 | AKT2 (0.46) | CYP1A2CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807860-A | ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS; HYPERLIPEMIA, ATHEROSCLEROSIS; ANTICHOLESTEROL AGENTS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0773218-A1 | N-(Piperazinylalkoxyphenyl)-N'phenylalkylurea derivatives as ACAT inhibitors for the treatment of atheroschlerosis | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-05-14 | — | — | EP | disclosed |