Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR1F | P30939 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946691 | 0.85 | HTR6 (0.75) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL30579484 | 0.84 | HTR6 (0.73) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL13137678 | 0.84 | HTR6 (0.73) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL18063387 | 0.81 | HTR6 (0.66) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL16704081 | 0.81 | HTR6 (0.69) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL7894537 | 0.81 | HTR6 (0.74) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL7902124 | 0.81 | HTR6 (0.73) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL946710 | 0.81 | HTR6 (0.73) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL7433712 | 0.79 | HTR6 (0.58) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL3033927 | 0.79 | HTR6 (0.71) | HTR6HTR1ADRD2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817879-A | PEPTIDE ANTAGONIST | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1998-10-06 | — | — | US | disclosed |
| US-5550251-A | CROSSREACTIVE WITH PEPTIDES BOUND BY G-PROTEIN LINKED RECEPTORS; USED AS THERAPEUTICAL, DIAGNOSTIC, AND PROPHYLITIC | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1996-08-27 | — | — | US | disclosed |
| US-5250564-A | Modulating activity of mammalian G-protein-linked receptor | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993012084-A1 | AROMATIC PEPTIDOMIMETICS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1993-06-24 | — | — | WO | disclosed |
| WO-1993011731-A2 | ALICYCLIC PEPTIDOMIMETICS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1993-06-24 | — | — | WO | disclosed |