Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639255 | 0.88 | PTGS2 (0.54) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8689158 | 0.87 | PTGS2 (0.46) | PTGS2PTGS1NPSR1CA2CA9 | |
| SCHEMBL8638997 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8691630 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8689437 | 0.84 | HTT (0.49) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL7059925 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8424012 | 0.80 | PTGS1 (0.42) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8689254 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8693265 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1LMNANPSR1CA2 | |
| SCHEMBL8421921 | 0.77 | CA2 (0.44) | PTGS2PTGS1LMNANPSR1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |