Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 15/20 | 0.35 |
| ▸ | MMP1 | P03956 | 14/20 | 0.35 |
| ▸ | MMP2 | P08253 | 12/20 | 0.35 |
| ▸ | MMP7 | P09237 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 9/20 | 0.33 |
| ▸ | MMP8 | P22894 | 4/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | MMP20 | O60882 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP15 | P51511 | 1/20 | 0.33 |
| ▸ | MMP16 | P51512 | 1/20 | 0.33 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.33 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721129 | 0.82 | MMP3 (0.49) | MMP3MMP1MMP2MMP7MMP9 | |
| SCHEMBL20721130 | 0.82 | MMP3 (0.49) | MMP3MMP1MMP2MMP7MMP9 | |
| SCHEMBL4676064 | 0.80 | HIF1A (0.37) | MMP3MMP1MMP2MMP7MMP9 | |
| SCHEMBL4300898 | 0.80 | MMP3 (0.37) | MMP3MMP1MMP2MMP7MMP9 | |
| SCHEMBL3556829 | 0.80 | HIF1A (0.37) | MMP3MMP1MMP2MMP7MMP9 | |
| SCHEMBL883447 | 0.78 | CA2 (0.43) | MMP3MMP1MMP2MMP7CNR2 | |
| SCHEMBL8357912 | 0.78 | CA2 (0.43) | MMP3MMP1MMP2MMP7CNR2 | |
| SCHEMBL21543027 | 0.74 | CNR2 (0.36) | MMP9CNR1CNR2PDF | |
| SCHEMBL11087412 | 0.74 | CA2 (0.31) | — | |
| SCHEMBL2784044 | 0.74 | CNR2 (0.36) | MMP9CNR1CNR2PDF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776933-A | Method of inhibiting protease | E. R. SQUIBB & SONS, INC. (US) | 1998-07-07 | — | — | US | disclosed |