Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 12/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.39 |
| ▸ | EIF2AK1 | Q9BQI3 | 4/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869571 | 0.87 | BRD4 (0.39) | EIF2AK3BRD4NPC1CYP1A2CYP3A4 | |
| SCHEMBL2373042 | 0.86 | EIF2AK3 (0.43) | EIF2AK3NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL870192 | 0.83 | EIF2AK3 (0.61) | EIF2AK3BRD4NPC1CYP1A2CYP3A4 | |
| SCHEMBL869091 | 0.77 | EIF2AK3 (0.74) | EIF2AK3RIPK1EIF2AK1EIF2AK2LCK | |
| SCHEMBL868758 | 0.77 | BRD4 (0.39) | EIF2AK3BRD4NPC1CYP1A2CYP3A4 | |
| SCHEMBL867820 | 0.77 | BRD4 (0.39) | EIF2AK3BRD4NPC1CYP1A2CYP3A4 | |
| SCHEMBL869335 | 0.74 | EIF2AK3 (0.66) | EIF2AK3BRD4NPC1CYP1A2CYP3A4 | |
| SCHEMBL3533819 | 0.73 | MAP4K4 (0.46) | RIPK1LCKAURKBMAPK13NTRK1 | |
| SCHEMBL14033124 | 0.73 | EIF2AK3 (0.70) | EIF2AK3CYP3A4EIF2AK1EIF2AK2LCK | |
| SCHEMBL869492 | 0.73 | EIF2AK3 (0.56) | EIF2AK3RIPK1EIF2AK1EIF2AK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885BRD4 1064/4885NPC1 564/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885BRD4 1064/4885NPC1 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.