Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.35 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867820 | 0.90 | BRD4 (0.39) | BRD4NPC1CYP1A2CYP3A4MAPT | |
| SCHEMBL869060 | 0.87 | EIF2AK3 (0.43) | BRD4NPC1CYP1A2CYP3A4MAPT | |
| SCHEMBL869492 | 0.85 | EIF2AK3 (0.56) | EIF2AK3 | |
| SCHEMBL869093 | 0.75 | EIF2AK3 (0.55) | EIF2AK3 | |
| SCHEMBL2373042 | 0.75 | EIF2AK3 (0.43) | NPC1MAPTRAB9ASMN1; SMN2EIF2AK3 | |
| SCHEMBL868758 | 0.74 | BRD4 (0.39) | BRD4NPC1CYP1A2CYP3A4MAPT | |
| SCHEMBL870192 | 0.74 | EIF2AK3 (0.61) | BRD4NPC1CYP1A2CYP3A4MAPT | |
| SCHEMBL14655630 | 0.72 | EIF2AK3 (0.61) | CYP3A4CYP11B1CYP11B2EIF2AK3 | |
| SCHEMBL868752 | 0.72 | EIF2AK3 (0.42) | CYP3A4CYP2C9EIF2AK3 | |
| SCHEMBL14655508 | 0.71 | CDK9 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | BRD4 1064/4885NPC1 564/4885CYP1A2 1446/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | BRD4 1064/4885NPC1 564/4885CYP1A2 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.