Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 13/20 | 0.50 |
| ▸ | CNR2 | P34972 | 13/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM6A | O15550 | 1/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM4B | O94953 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685522 | 0.90 | LMNA (0.64) | CNR1CNR2MEN1ABCC4LMNA | |
| SCHEMBL2546290 | 0.89 | CNR1 (0.51) | CNR1CNR2ATMPRKCBGSK3B | |
| SCHEMBL8513279 | 0.87 | CNR1 (0.51) | CNR1CNR2ATMKDM4EPRKCB | |
| SCHEMBL27787562 | 0.87 | CNR1 (0.49) | CNR1CNR2MEN1KMT2AATM | |
| SCHEMBL9171932 | 0.86 | CNR2 (0.64) | CNR1CNR2KDM4E | |
| SCHEMBL28072744 | 0.85 | CNR2 (0.69) | CNR1CNR2 | |
| SCHEMBL19675321 | 0.84 | HTR3A (0.48) | CNR1CNR2ATMKDM4E | |
| SCHEMBL28146834 | 0.84 | KDM4E (0.48) | CNR1CNR2ATMKDM4EKDM6B | |
| SCHEMBL15897857 | 0.83 | CNR1 (0.48) | CNR1CNR2ATMKDM4EKDM6B | |
| SCHEMBL13204148 | 0.82 | CNR1 (0.48) | CNR1CNR2ATMPRKCBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012114252-A1 | NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |
| EP-0712408-B1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | DOMPE SPA (IT) | 1998-10-28 | — | — | EP | disclosed |
| US-5750536-A | ANTI-ASTHMATICS, TREATMENT OF PAIN SENSITIVITY | DOMPE ' SPA (IT) | 1998-05-12 | — | — | US | disclosed |