Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637083 | 0.91 | RXRA (0.44) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8637575 | 0.90 | PTGS2 (0.52) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8641600 | 0.90 | PTGS2 (0.44) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8688673 | 0.88 | PTGS2 (0.43) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8637137 | 0.88 | RXRA (0.43) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8689185 | 0.87 | PTGS2 (0.57) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8691137 | 0.87 | PTGS2 (0.42) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8693656 | 0.86 | PTGS2 (0.45) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8691654 | 0.86 | PTGS2 (0.45) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8689324 | 0.86 | PTGS2 (0.45) | RXRANR1H2NR1H3PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |