Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 13/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.68 |
| ▸ | STK3 | Q13188 | 7/20 | 0.68 |
| ▸ | STK4 | Q13043 | 5/20 | 0.68 |
| ▸ | BTK | Q06187 | 2/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | STK25 | O00506 | 1/20 | 0.68 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.68 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.68 |
| ▸ | STK17B | O94768 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17503056 | 1.00 | EGFR (0.68) | EGFRERBB2STK3STK4BTK | |
| Trifluoroacetic Acid SCHEMBL868416 | 0.97 | EGFR (0.65) | EGFRERBB2STK3STK4BTK | |
| Bromide SCHEMBL867611 | 0.89 | EGFR (0.67) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL17503010 | 0.89 | EGFR (0.67) | EGFRERBB2STK3STK4BTK | |
| Trifluoroacetic Acid SCHEMBL17503023 | 0.87 | EGFR (0.63) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL4540604 | 0.86 | EGFR (0.82) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL4540611 | 0.86 | EGFR (0.82) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL2386955 | 0.86 | EGFR (0.83) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL29801718 | 0.86 | EGFR (0.83) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL2386963 | 0.86 | EGFR (0.83) | EGFRERBB2STK3STK4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3031807-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | Auckland UniServices Limited (NZ) | 2016-06-15 | — | — | EP | disclosed |
| EP-2406262-B1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LTD (NZ) | 2016-02-17 | — | — | EP | disclosed |
| US-20160002222-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2016-01-07 | — | — | US | disclosed |
| US-9073916-B2 | Prodrug forms of kinase inhibitors and their use in therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2015-07-07 | — | — | US | disclosed |
| US-20120077811-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077811-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | NTRK3, TK1, TNNI3K | HRH2 1027/4885EGFR 48/4885ERBB2 7/4885 |
| US-20160002222-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | NTRK3, TK1, TNNI3K | HRH2 1090/4885EGFR 41/4885ERBB2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.