Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.56 |
| ▸ | EDNRB | P24530 | 7/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080551 | 0.84 | AURKA (0.52) | AURKADHFRLMNATSHR | |
| SCHEMBL4617033 | 0.84 | ALDH1A1 (0.54) | EDNRAEDNRBLMNATSHRCASP1 | |
| SCHEMBL8350452 | 0.79 | EDNRA (0.54) | EDNRAEDNRBFBP1CASP1 | |
| SCHEMBL7404641 | 0.77 | SCN9A (0.53) | EDNRAEDNRBFBP1 | |
| SCHEMBL30970210 | 0.77 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL1094168 | 0.76 | KDM4E (0.55) | EDNRAEDNRBAURKADHFRLMNA | |
| SCHEMBL31681365 | 0.76 | AURKA (0.67) | EDNRAEDNRBAURKADHFRLMNA | |
| SCHEMBL3837982 | 0.76 | NFKBIA (0.60) | EDNRAAURKADHFRLMNATSHR | |
| SCHEMBL7230668 | 0.75 | EDNRA (0.54) | EDNRAEDNRBFBP1CASP1 | |
| SCHEMBL10888517 | 0.75 | NFKBIA (0.58) | EDNRAAURKADHFRLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998004260-A1 | SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-05 | — | — | WO | claimed |
| WO-1998004260-A1 | SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-05 | — | — | WO | disclosed |