Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28261311 | 0.95 | TSHR (0.38) | TSHRHSD17B10SLC22A1TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7155401 | 0.89 | TSHR (0.42) | TSHRHSD17B10SLC22A1TDP1ALDH1A1 | |
| SCHEMBL1275398 | 0.86 | TSHR (0.44) | TSHRHSD17B10SLC22A1TDP1ALDH1A1 | |
| Water SCHEMBL11566007 | 0.83 | TSHR (0.42) | TSHRHSD17B10SLC22A1TDP1ALDH1A1 | |
| Bromide SCHEMBL17292977 | 0.83 | TSHR (0.42) | TSHRHSD17B10SLC22A1TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11582717 | 0.83 | TSHR (0.39) | TSHRTDP1ALDH1A1 | |
| SCHEMBL1275992 | 0.80 | TSHR (0.41) | TSHRTDP1ALDH1A1 | |
| SCHEMBL9422185 | 0.78 | DNM1 (0.46) | TSHRHSD17B10SLC22A1ALDH1A1 | |
| Water SCHEMBL319957 | 0.77 | TSHR (0.39) | TSHRTDP1ALDH1A1 | |
| Iodide SCHEMBL28517508 | 0.77 | TSHR (0.39) | TSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753214-A | SILYLATED PEPTIDES | SEIWA KASEI CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0699431-A1 | Base material for cosmetics and uses of the same | SEIWA KASEI CO., LTD. (JP) | 1996-03-06 | — | — | EP | disclosed |