Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 15/20 | 0.56 |
| ▸ | EIF2AK3 | Q9NZJ5 | 4/20 | 0.56 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.56 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NEK4 | P51957 | 1/20 | 0.56 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.56 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.56 |
| ▸ | MERTK | Q12866 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869334 | 0.87 | EIF2AK3 (0.55) | RIPK1EIF2AK3EIF2AK2EIF2AK1CYP11B1 | |
| SCHEMBL16386454 | 0.80 | RIPK1 (0.59) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL869180 | 0.79 | RIPK1 (0.66) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL30774488 | 0.79 | RIPK1 (0.48) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL868831 | 0.78 | RIPK1 (0.65) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL13860439 | 0.76 | EIF2AK3 (0.55) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL14655478 | 0.75 | RIPK1 (0.56) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL869066 | 0.74 | RIPK1 (0.55) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL16660364 | 0.74 | RIPK1 (0.66) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL869349 | 0.74 | EIF2AK3 (0.79) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | RIPK1 218/4885EIF2AK3 16/4885EIF2AK2 174/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | RIPK1 218/4885EIF2AK3 16/4885EIF2AK2 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.