Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 9/20 | 0.55 |
| ▸ | EIF2AK1 | Q9BQI3 | 4/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 9/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NEK4 | P51957 | 1/20 | 0.55 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.55 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374124 | 0.88 | EIF2AK3 (0.69) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL2374303 | 0.88 | EIF2AK3 (0.60) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL869349 | 0.84 | EIF2AK3 (0.79) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL2374826 | 0.80 | EIF2AK3 (0.56) | EIF2AK3EIF2AK1LCKAURKBEIF2AK2 | |
| SCHEMBL14655478 | 0.78 | RIPK1 (0.56) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL869481 | 0.76 | RIPK1 (0.56) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL16386454 | 0.76 | RIPK1 (0.59) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL869180 | 0.75 | RIPK1 (0.66) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL868831 | 0.75 | RIPK1 (0.65) | EIF2AK3EIF2AK1RIPK1LCKAURKB | |
| SCHEMBL869066 | 0.74 | RIPK1 (0.55) | EIF2AK3EIF2AK1RIPK1LCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158123-A1 | COMPOUNDS AND METHODS FOR TREATING INSULIN RESISTANCE SYNDROME | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-11-22 | — | — | WO | claimed |