Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691832 | 0.85 | — | — | |
| SCHEMBL8875420 | 0.85 | TSHR (0.48) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL375634 | 0.82 | LMNA (0.53) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL8696479 | 0.81 | TSHR (0.52) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL18073440 | 0.80 | TSHR (0.56) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL15721706 | 0.80 | TSHR (0.56) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL30883031 | 0.80 | LMNA (0.58) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL28778289 | 0.79 | TSHR (0.50) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL1766162 | 0.79 | LMNA (0.50) | TSHRLMNASLC22A6PMP22NFKB1 | |
| SCHEMBL1766170 | 0.79 | LMNA (0.50) | TSHRLMNASLC22A6PMP22NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998035677-A1 | NON-SEDATING HISTAMINE ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | BRIDGE PHARMA, INC. (US) | 1998-08-20 | — | — | WO | claimed |
| WO-1998035677-A1 | NON-SEDATING HISTAMINE ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | BRIDGE PHARMA, INC. (US) | 1998-08-20 | — | — | WO | disclosed |