Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PAM | P19021 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29787058 | 0.84 | ALDH1A1 (0.49) | CES1HIF1ASMN1; SMN2SLC6A2PTPN1 | |
| SCHEMBL1081531 | 0.81 | SMN1; SMN2 (0.69) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL5647919 | 0.81 | SLC6A2 (0.53) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL12902954 | 0.78 | CES1 (0.59) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL3761802 | 0.76 | SMN1; SMN2 (0.57) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL16816903 | 0.75 | SMN1; SMN2 (0.67) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL2336417 | 0.75 | SMN1; SMN2 (0.67) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL17498702 | 0.75 | SMN1; SMN2 (0.67) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL29187272 | 0.74 | CES1 (0.55) | CES1HIF1ASMN1; SMN2CES2AKR1B1 | |
| SCHEMBL215167 | 0.73 | CES1 (0.53) | CES1HIF1ASMN1; SMN2CES2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760248-A | HAVING IMPROVED METABOLIC STABILITY | A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-06-02 | — | — | US | disclosed |
| WO-1995015311-A1 | TACHYKININ ANTAGONISTS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1995-06-08 | — | — | WO | disclosed |