Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.69 |
| ▸ | HTR1D | P28221 | 15/20 | 0.69 |
| ▸ | HTR1B | P28222 | 15/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 5/20 | 0.64 |
| ▸ | HTR6 | P50406 | 5/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.64 |
| ▸ | STS | P08842 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8691219 | 0.90 | HTR1A (0.85) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| SCHEMBL8759945 | 0.87 | HTR1A (0.68) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| SCHEMBL8693877 | 0.87 | HTR1A (0.67) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| SCHEMBL8691191 | 0.86 | HTR1A (0.68) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| Fumaric Acid SCHEMBL8692233 | 0.85 | HTR1A (0.86) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| Fumaric Acid SCHEMBL8691252 | 0.83 | HTR1A (0.71) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| SCHEMBL8760766 | 0.82 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8759779 | 0.78 | HTR1A (1.00) | HTR1AHTR1DHTR1BMAPTHTR2C | |
| SCHEMBL15819174 | 0.77 | HTR3E (0.57) | HTR1AHTR1DHTR1BMAPTALDH1A1 | |
| SCHEMBL6720399 | 0.77 | MAPT (0.59) | HTR1AHTR1DHTR1BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789412-A | 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTOR ANTAGONISTS FOR THE CURATIVE OR PREVENTIVE TREATMENT OF PAIN, DEPRESSION, OBSESSIVE COMPULSIVE DISORDERS, ANXIETY OR PANIC ATTACK, OR CANCER | PIERRE FABRE MEDICAMENT (FR) | 1998-08-04 | — | — | US | disclosed |
| EP-0773937-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996002525-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1996-02-01 | — | — | WO | disclosed |