Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 5/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929770 | 0.83 | CYP3A4 (0.67) | ICMTCYP3A4CYP2E1CYP2A6GRM5 | |
| SCHEMBL30618761 | 0.81 | ICMT (0.76) | ICMTCYP3A4CYP2E1CYP2A6GRM5 | |
| SCHEMBL20817583 | 0.81 | ICMT (0.76) | ICMTCYP3A4CYP2E1CYP2A6GRM5 | |
| SCHEMBL4400768 | 0.80 | ALDH1A1 (0.56) | ICMTCYP3A4CYP2E1CYP2A6GRM5 | |
| SCHEMBL17166601 | 0.78 | CYP3A4 (0.61) | ICMTCYP3A4CYP2E1CYP2A6GRM5 | |
| SCHEMBL20817631 | 0.77 | ICMT (1.00) | ICMTCYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL20817561 | 0.77 | ICMT (0.78) | ICMTCYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL20817579 | 0.77 | ICMT (1.00) | ICMTCYP3A4GRM5CYP1A2CYP2D6 | |
| SCHEMBL30618781 | 0.77 | ICMT (0.78) | ICMTCYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL30618726 | 0.77 | ICMT (1.00) | ICMTCYP3A4GRM5CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0703913-B1 | IMIDAZOLES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0703913-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029299-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |