Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698594 | 0.85 | PTPN1 (0.39) | EDNRBPTPN1TP53 | |
| SCHEMBL8697633 | 0.78 | POLB (0.37) | EDNRBPTPN1 | |
| SCHEMBL8697275 | 0.78 | PTPN1 (0.42) | EDNRBPTPN1 | |
| SCHEMBL8697591 | 0.77 | PTPN1 (0.46) | PTPN1TP53 | |
| SCHEMBL8697402 | 0.74 | NTRK1 (0.39) | — | |
| SCHEMBL8702544 | 0.73 | EDNRB (0.38) | EDNRBPTPN1TP53 | |
| SCHEMBL8547930 | 0.73 | EDNRB (0.47) | EDNRBEDNRAPTPN1PPARG | |
| SCHEMBL8704430 | 0.72 | EDNRB (0.34) | EDNRBPTPN1 | |
| SCHEMBL8551472 | 0.72 | EDNRB (0.43) | EDNRBEDNRAPTPN1TP53 | |
| SCHEMBL8549234 | 0.72 | EDNRB (0.52) | EDNRBEDNRAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998042709-A1 | ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-10-01 | — | — | WO | disclosed |