Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548607 | 0.94 | EDNRB (0.45) | EDNRBDYRK1APLA2G2APDCD1CD274 | |
| SCHEMBL8547859 | 0.92 | EDNRB (0.44) | EDNRBDYRK1AFFAR1PLA2G2APTPN1 | |
| SCHEMBL8549318 | 0.92 | EDNRB (0.43) | EDNRBFFAR1PTPN1PDCD1CD274 | |
| SCHEMBL8547930 | 0.89 | EDNRB (0.47) | EDNRBPTPN1EDNRAKDM4EGAA | |
| SCHEMBL8549234 | 0.88 | EDNRB (0.52) | EDNRBPLA2G2APTPN1EDNRAKDM4E | |
| SCHEMBL8547217 | 0.86 | EDNRB (0.46) | EDNRBDYRK1APLA2G2APDCD1CD274 | |
| SCHEMBL8546037 | 0.86 | EDNRB (0.60) | EDNRBPLA2G2APTPN1EDNRAKDM4E | |
| SCHEMBL8551108 | 0.85 | EDNRB (0.50) | EDNRBDYRK1APLA2G2AEDNRAPPARD | |
| SCHEMBL8547478 | 0.85 | EDNRB (0.43) | EDNRBPTPN1EDNRAKDM4EGAA | |
| SCHEMBL8548858 | 0.84 | EDNRB (0.45) | EDNRBFFAR1PTPN1EDNRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |