Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697649 | 0.84 | CNR2 (0.42) | PDE3BPDE3AALDH1A1KDM4ECNR1 | |
| SCHEMBL8696774 | 0.77 | NPC1 (0.46) | PDE3BPDE3AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8694309 | 0.73 | PDE3B (0.45) | PDE3BPDE3AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4415630 | 0.71 | CNR2 (0.70) | ALDH1A1SMN1; SMN2KDM4ELMNACNR1 | |
| SCHEMBL9542617 | 0.70 | TDP1 (0.50) | SMN1; SMN2KDM4ELMNACNR1CNR2 | |
| SCHEMBL8692878 | 0.70 | HTT (0.43) | PDE3BPDE3AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8693592 | 0.70 | HTT (0.42) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL16022002 | 0.69 | BAZ2B (0.49) | ALDH1A1KDM4ELMNAGAAHPGD | |
| SCHEMBL8695084 | 0.68 | EGFR (0.44) | PDE3BPDE3AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9056605 | 0.68 | PDE3B (0.42) | PDE3BPDE3AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712296-A | Substituted pyridines and 2-oxo-1,2-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1998-01-27 | — | — | US | disclosed |
| US-5492923-A | DRUG FOR TREATING ARTERIAL HYPERTENSION AND ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-20 | — | — | US | disclosed |