Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.60 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.60 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13895513 | 0.87 | HTT (0.74) | HTTKEAP1NFE2L2TGM2POLB | |
| SCHEMBL8697470 | 0.87 | FAAH (0.61) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL917677 | 0.86 | HTT (0.65) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL4211608 | 0.86 | ALDH1A1 (0.58) | HTTKEAP1NFE2L2TGM2POLB | |
| SCHEMBL6748819 | 0.86 | HTT (0.72) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL18254066 | 0.85 | HTT (0.81) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL30605297 | 0.85 | HTT (0.63) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL15346534 | 0.84 | HTT (0.79) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL9874334 | 0.84 | HTT (0.79) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 | |
| SCHEMBL9340146 | 0.84 | HTT (0.79) | HTTKEAP1NFE2L2TGM2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1208412-A | Gonadotropin releasing hormone antagonists | MERCK & CO INC (US) | 1999-02-17 | — | — | CN | disclosed |
| US-5849764-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 1998-12-15 | — | — | US | disclosed |