⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12096478 | 1.00 | — | — | |
| SCHEMBL2643485 | 0.70 | GAA (0.33) | — | |
| SCHEMBL460544 | 0.67 | GAA (0.36) | — | |
| SCHEMBL5904469 | 0.67 | TNKS2 (0.36) | — | |
| SCHEMBL13324809 | 0.65 | — | — | |
| SCHEMBL23446988 | 0.63 | — | — | |
| SCHEMBL20067380 | 0.63 | BRD4 (0.31) | — | |
| SCHEMBL20067379 | 0.62 | PBRM1 (0.31) | — | |
| SCHEMBL4232316 | 0.60 | GAA (0.36) | — | |
| SCHEMBL11443711 | 0.60 | IDO1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859815-B2 | Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis | BIAL-PORTELA & C.A., S.A. (PT) | 2014-10-14 | — | — | US | claimed |
| US-20120077973-A1 | Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis | BIAL - PORTELA & CA, S.A. (PT) | 2012-03-29 | — | — | US | claimed |
| US-8859815-B2 | Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis | BIAL-PORTELA & C.A., S.A. (PT) | 2014-10-14 | — | — | US | disclosed |
| EP-2683691-A2 | PROCESS FOR THE PREPARATION OF (S)-(+)-OR (R)-(-)-10 HYDROXY DIHYDRODIBENZ[B,F]AZEPINES BY ENANTIOSELECTIVE REDUCTION OF 10, 11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINES AND POLYMORPHS THEREOF | Jubilant Life Sciences Limited (IN) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012120356-A2 | PROCESS FOR THE PREPARATION OF (S)-(+)-OR (R)-(-)-10 HYDROXY DIHYDRODIBENZ[B,F]AZEPINES BY ENANTIOSELECTIVE REDUCTION OF 10, 11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINES AND POLYMORPHS THEREOF | JUBILANT LIFE SCIENCES LIMITED (IN) | 2012-09-13 | — | — | WO | disclosed |
| EP-1812384-B1 | SULPHONYLATED DIPHENYLETHYLENEDIAMINES, METHOD FOR THEIR PREPARATION AND USE IN TRANSFER HYDROGENATION CATALYSIS | BIAL PORTELA & CA SA (PT) | 2012-07-04 | — | — | EP | disclosed |
| US-20120077973-A1 | Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis | BIAL - PORTELA & CA, S.A. (PT) | 2012-03-29 | — | — | US | disclosed |
| US-7667075-B2 | hydrogenation catalysts comprising the reaction products of sulphonylated diamines with metal compounds, used for reduction of carbonyl compounds to the corresponding chiral alcohols and imines to the corresponding chiral amines | BIAL - PORTELA & CA, S.A. (PT) | 2010-02-23 | — | — | US | disclosed |
| US-20090326274-A1 | Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis | BIAL - PORTELA & CA, .S.A. (PT) | 2009-12-31 | — | — | US | disclosed |
| EP-1935880-A1 | Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis | Portela & Ca., S.A. (PT) | 2008-06-25 | — | — | EP | disclosed |
| US-20080081930-A1 | hydrogenation catalysts comprising the reaction products of sulphonylated diamines with metal compounds, used for reduction of carbonyl compounds to the corresponding chiral alcohols and imines to the corresponding chiral amines | PORTELA & C.A., S.A. | 2008-04-03 | — | — | US | disclosed |
| EP-1812384-A1 | SULPHONYLATED DIPHENYLETHYLENEDIAMINES, METHOD FOR THEIR PREPARATION AND USE IN TRANSFER HYDROGENATION CATALYSIS | Portela & CA SA (PT) | 2007-08-01 | — | — | EP | disclosed |
| US-20060142566-A1 | Enantioselective process for the preparation of both enantiomers of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide and new crystal forms thereof | NOVARTIS AG (CH) | 2006-06-29 | — | — | US | disclosed |
| US-20060142566-A1 | Enantioselective process for the preparation of both enantiomers of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide and new crystal forms thereof | NOVARTIS AG (CH) | 2006-06-29 | — | — | US | disclosed |
| WO-2006054115-A1 | SULPHONYLATED DIPHENYLETHYLENEDIAMINES, METHOD FOR THEIR PREPARATION AND USE IN TRANSFER HYDROGENATION CATALYSIS | PORTELA & CA., S.A. (PT) | 2006-05-26 | — | — | WO | disclosed |
| CN-1703404-A | Enantioselective process for preparing two enantiomers of 10, 11-dihydro-10-hydroxy-5H-dibenzo (b, f) azepine * -5-carboxamide and novel crystalline forms thereof | NOVARTIS AG (CH) | 2005-11-30 | — | — | CN | disclosed |
| EP-1551808-A1 | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ b,f AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF | Novartis AG (CH) | 2005-07-13 | — | — | EP | disclosed |
| EP-1551808-A1 | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ b,f AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF | Novartis AG (CH) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004031155-A1 | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF | NOVARTIS AG (CH) | 2004-04-15 | — | — | WO | disclosed |
| WO-2004031155-A1 | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF | NOVARTIS AG (CH) | 2004-04-15 | — | — | WO | disclosed |