Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700494 | 0.80 | KDM4E (0.46) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL30170803 | 0.74 | KDM4E (0.52) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL8482565 | 0.72 | KDM4E (0.73) | KDM4EHSD17B10L3MBTL1ALDH1A1POLB | |
| SCHEMBL10501732 | 0.72 | KDM4E (0.78) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL7435743 | 0.72 | TSHR (1.00) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL15846056 | 0.72 | ALDH1A1 (0.58) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL6410314 | 0.71 | KDM4E (0.72) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL14085807 | 0.71 | KDM4E (0.76) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL844974 | 0.71 | CSNK1D (0.52) | KDM4EHSD17B10TSHRMAPK10TDP1 | |
| SCHEMBL16632075 | 0.71 | ALDH1A1 (0.60) | KDM4EHSD17B10TSHRMAPK10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834468-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS, ANALGESICS TREATING RHEUMATIC DISEASE, BONE DISORDER, INJURIES | ZENECA LIMITED (GB) | 1998-11-10 | — | — | US | disclosed |