Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697553 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1CYP2C19NPSR1CYP1A2 | |
| SCHEMBL7312805 | 0.73 | LMNA (0.71) | KDM4EALDH1A1CYP2C19NPSR1CYP1A2 | |
| SCHEMBL21750022 | 0.72 | BRD4 (0.52) | PPIABRD4ALDH1A1CYP2C19NPSR1 | |
| SCHEMBL28877532 | 0.72 | ALDH1A1 (0.56) | PPIAALDH1A1HPGDHTTLMNA | |
| SCHEMBL27968967 | 0.70 | TSHR (0.53) | KDM4EPPIAALDH1A1HPGDHTT | |
| SCHEMBL8980579 | 0.70 | TSHR (0.53) | KDM4EPPIAALDH1A1NPSR1HPGD | |
| SCHEMBL29105286 | 0.69 | BRD4 (0.63) | PPIABRD4ALDH1A1CYP2C19NPSR1 | |
| SCHEMBL14855710 | 0.68 | KDM4E (0.71) | KDM4ERAB9AALDH1A1CYP2C19NPSR1 | |
| SCHEMBL3931825 | 0.68 | TDP1 (0.51) | KDM4EGAAALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL28957917 | 0.68 | TSHR (0.50) | RAB9APPIAALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834468-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS, ANALGESICS TREATING RHEUMATIC DISEASE, BONE DISORDER, INJURIES | ZENECA LIMITED (GB) | 1998-11-10 | — | — | US | disclosed |