Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763073 | 0.81 | KDM4E (0.78) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL9989066 | 0.81 | KDM4E (0.80) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL8696622 | 0.80 | KDM4E (0.74) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL10488237 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL30621954 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL26602361 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL8696624 | 0.74 | ATM (0.61) | KDM4ENPC1RAB9AMEN1KMT2A | |
| SCHEMBL31453039 | 0.73 | KDM4E (0.60) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL31453064 | 0.72 | KDM4E (0.62) | KDM4EALDH1A1MCL1NPC1RAB9A | |
| SCHEMBL1065472 | 0.72 | MCL1 (0.71) | KDM4EALDH1A1MCL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767133-A | Secondary amines as antidiabetic and antiobesity agents | PFIZER INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0703911-B1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| US-5627200-A | β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia | PFIZER INC (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0703911-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029290-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |