Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL8694945 | 0.95 | MAPT (0.31) | MAPTTP53ALDH1A1LMNAMAPK1 | |
| Benzoic Acid SCHEMBL8693574 | 0.87 | DGAT1 (0.31) | ALDH1A1 | |
| Benzoic Acid SCHEMBL8552961 | 0.74 | MEN1 (0.30) | MAPK1 | |
| Benzoic Acid SCHEMBL8551806 | 0.73 | MEN1 (0.31) | LMNAMAPK1 | |
| Benzoic Acid SCHEMBL8548987 | 0.71 | NPC1 (0.35) | MAPTTP53ALDH1A1LMNAMAPK1 | |
| Benzoic Acid SCHEMBL8436196 | 0.70 | PDPK1 (0.33) | MAPK1 | |
| Benzoic Acid SCHEMBL8549411 | 0.69 | ACHE (0.37) | MAPTTP53ALDH1A1LMNAMAPK1 | |
| Benzoic Acid SCHEMBL8550961 | 0.65 | PFKFB3 (0.31) | — | |
| Benzoic Acid SCHEMBL8435537 | 0.64 | PDPK1 (0.33) | MAPTLMNAMAPK1 | |
| Benzoic Acid SCHEMBL8709658 | 0.62 | TMEM97 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |