Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.38 |
| ▸ | MAOA | P21397 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697365 | 0.78 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BALDH1A1KDM4E | |
| SCHEMBL22390400 | 0.78 | ADORA2A (0.43) | ADORA2AADORA1MAOAALDH1A1KDM4E | |
| SCHEMBL22390404 | 0.78 | KDM4E (0.57) | ADRA1DADRA1AADRA1BADORA2AADORA1 | |
| SCHEMBL22390457 | 0.78 | KDM4E (0.45) | ADORA2AADORA1MAOAALDH1A1KDM4E | |
| SCHEMBL8697211 | 0.77 | ALDH1A1 (0.55) | ADRA1DADRA1AADRA1BALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL22390503 | 0.76 | KDM4E (0.44) | ADORA2AADORA1MAOAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL22390484 | 0.76 | KDM4E (0.55) | ADRA1DADRA1AADRA1BADORA2AADORA1 | |
| SCHEMBL21524884 | 0.76 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BALDH1A1HTT | |
| SCHEMBL22073784 | 0.69 | HTT (0.57) | MAOAALDH1A1KDM4EMAPTHTT | |
| Hydrochloric Acid SCHEMBL22390505 | 0.68 | HTT (0.56) | MAOAALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834460-A | FOR TREATMENT OF BRAIN OR PSYCHOLOGICAL DISORDERS, ALZHEIMER*S DISEASE, MENTAL RETARDATION OR AUTISM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0696586-A1 | SERINE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |