SCHEMBL8699002

SCHEMBL8699002

CCOC(=O)Nc1cc(NS(=O)(=O)N(C)C)c(Cl)cc1F

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PIK3C3 Q8NEB9 1/20 0.46
ALDH1A1 P00352 4/20 0.43
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
KCNQ3 O43525 1/20 0.37
KCNQ2 O43526 1/20 0.37
KCNQ4 P56696 1/20 0.37
KCNQ5 Q9NR82 1/20 0.37
HPGD P15428 1/20 0.37
SCN9A Q15858 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
KDM4E B2RXH2 1/20 0.36
KDR P35968 1/20 0.36
TLR4 O00206 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9123724 0.86 ALDH1A1 (0.46) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL9120354 0.86 ALDH1A1 (0.46) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL8697533 0.81 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19HPGD
SCHEMBL8699915 0.80 ALDH1A1 (0.52) PIK3C3ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL8697590 0.80 SMN1; SMN2 (0.48) PIK3C3ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL8084401 0.79 ALDH1A1 (0.51) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL7220721 0.79 ALDH1A1 (0.54) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL24170851 0.78 SMN1; SMN2 (0.53) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL8698998 0.78 ALDH1A1 (0.42) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL709376 0.77 SCN9A (0.43) ALDH1A1CYP2C19SMN1; SMN2HPGDSCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998028280-A1 CERTAIN 3-[2,4-DISUBSTITUTED-5-(SUBSTITUTED AMINO)PHENYL]-1-SUBSTITUTED-6-TRIFLUOROMETHYL-2,4-(1H,3H)-PYRIMIDINEDIONE DERIVATIVES AS HERBICIDES FMC CORPORATION (US) 1998-07-02 WO disclosed