SCHEMBL709376

SCHEMBL709376

CCOC(=O)Nc1cc(C(=O)NS(=O)(=O)N(C)C(C)C)c(Cl)cc1F

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 13/20 0.43
ALDH1A1 P00352 3/20 0.43
HPGD P15428 2/20 0.43
CYP2C19 P33261 1/20 0.39
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL712255 0.90 SCN9A (0.45) SCN9ACYP2C19
SCHEMBL25047105 0.84 SCN9A (0.43) SCN9ACYP2C19
SCHEMBL9878589 0.83 SMN1; SMN2 (0.52) ALDH1A1HPGDCYP2C19LMNAMAPT
SCHEMBL710134 0.81 ALDH1A1 (0.47) ALDH1A1HPGDCYP2C19LMNAMAPT
SCHEMBL10242588 0.79 SCN9A (0.40) SCN9AHPGDCYP2C19
SCHEMBL25047377 0.78 ALDH1A1 (0.57) ALDH1A1HPGDCYP2C19LMNAMAPT
SCHEMBL25046395 0.77 SCN9A (0.42) SCN9AHPGDCYP2C19LMNAMAPT
SCHEMBL713577 0.77 SCN9A (0.46) SCN9ACYP2C19
SCHEMBL9877864 0.77 ALDH1A1 (0.43) ALDH1A1HPGDCYP2C19LMNAMAPT
SCHEMBL8699002 0.77 PIK3C3 (0.46) SCN9AALDH1A1HPGDCYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9920002-B2 Methods for producing sulfonic acid diamides BASF SE (DE) 2018-03-20 US disclosed
US-8252925-B2 Method for the production of 3-phenyl(thio)uracils and dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2012-08-28 US disclosed
US-8124818-B2 Method for the production of 3-phenyl(thio) uracils and dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2012-02-28 US disclosed
US-20110152522-A1 METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS BASF AKTIENGESSELSCHAFT (DE) 2011-06-23 US disclosed
US-20110152522-A1 METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS BASF AKTIENGESSELSCHAFT (DE) 2011-06-23 US disclosed
US-20100222586-A1 Methods for Producing Sulfonic Acid Diamides BASF SE (DE) 2010-09-02 US disclosed
EP-2200978-A1 METHOD FOR PRODUCING SULFONIC ACID DIAMIDES BASF SE (DE) 2010-06-30 EP disclosed
WO-2009050120-A1 METHOD FOR PRODUCING SULFONIC ACID DIAMIDES BASF SE (DE) 2009-04-23 WO disclosed
US-20080033174-A1 Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2008-02-07 US disclosed
US-20080033174-A1 Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2008-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222586-A1 Methods for Producing Sulfonic Acid Diamides CBR3, SQOR, SRM SCN9A 429/4885ALDH1A1 1357/4885HPGD 2212/4885
US-20080033174-A1 Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils TPMT, TYMP, TYMS SCN9A 4240/4885ALDH1A1 233/4885HPGD 505/4885
US-20110152522-A1 METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS TPMT, TYMP, TYMS SCN9A 4240/4885ALDH1A1 233/4885HPGD 505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.