Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669085 | 0.81 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL31683946 | 0.79 | PNMT (0.64) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL2246761 | 0.77 | GAA (0.47) | MAPTALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL2245283 | 0.77 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL14508405 | 0.77 | CA1 (0.41) | MAPTALDH1A1GAAKMT2A | |
| SCHEMBL12355694 | 0.76 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL2246074 | 0.76 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1016536 | 0.76 | MAPT (0.43) | PNMTADRA2AADRA2BADRA2CDGAT1 | |
| SCHEMBL17248041 | 0.75 | MAPT (0.54) | PNMTADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL31334246 | 0.75 | MAPT (0.61) | DGAT1MAPTLMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005651-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYL QUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1998-02-12 | — | — | WO | disclosed |