Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073283 | 0.83 | HSD17B1 (0.47) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL1018625 | 0.82 | TSHR (0.43) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL19055480 | 0.82 | CYP1A2 (0.43) | MAPTLMNAALDH1A1GAATSHR | |
| SCHEMBL8304087 | 0.79 | HSD17B10 (0.55) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL7075428 | 0.77 | BRD4 (0.42) | TSHRHSD17B10 | |
| SCHEMBL7076747 | 0.76 | HSD17B1 (0.45) | MAPTALDH1A1GAATSHRHSD17B10 | |
| SCHEMBL8699077 | 0.76 | PNMT (0.49) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL5775643 | 0.75 | TSHR (0.46) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL16333559 | 0.75 | ALDH1A1 (0.42) | SIRT2ALDH1A1GAAADRA2APNMT | |
| SCHEMBL5780446 | 0.74 | TSHR (0.44) | MAPTKDM4EALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |