SCHEMBL8699119

SCHEMBL8699119

CCc1cc(NC(=S)N2CCN(c3cccc(Cl)c3)CC2)c(OC)nc1C

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.55
LMNA P02545 4/20 0.50
RXFP1 Q9HBX9 1/20 0.50
ALDH1A1 P00352 6/20 0.49
NPC1 O15118 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
MAPT P10636 6/20 0.48
GAA P10253 1/20 0.48
PHGDH O43175 1/20 0.48
KMT2A Q03164 5/20 0.48
MEN1 O00255 4/20 0.48
POLB P06746 3/20 0.48
HTT P42858 2/20 0.48
HPGD P15428 1/20 0.47
PKM P14618 1/20 0.47
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
MAPK1 P28482 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6651279 0.90 PHGDH (0.53) KDM4ELMNAALDH1A1NPC1SMN1; SMN2
SCHEMBL6651274 0.90 MEN1 (0.54) LMNAALDH1A1NPC1SMN1; SMN2MAPT
SCHEMBL8700453 0.90 RBP4 (0.56) KDM4ELMNAALDH1A1SMN1; SMN2MAPT
SCHEMBL8699629 0.89 KDM4E (0.57) KDM4ELMNARXFP1ALDH1A1NPC1
SCHEMBL6653052 0.86 PHGDH (0.56) LMNAALDH1A1NPC1SMN1; SMN2MAPT
SCHEMBL6653887 0.85 PHGDH (0.52) LMNAALDH1A1NPC1PHGDHKMT2A
SCHEMBL6653829 0.84 KMT2A (0.55) KDM4ELMNAALDH1A1PHGDHKMT2A
SCHEMBL8700078 0.84 MAPT (0.56) KDM4EALDH1A1SMN1; SMN2MAPTGAA
SCHEMBL6654791 0.83 PHGDH (0.43) KDM4ELMNAALDH1A1NPC1SMN1; SMN2
SCHEMBL6650903 0.83 KDM4E (0.59) KDM4ELMNARXFP1ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5780472-A ANTITUMOR AGENTS SAMJIN PHARMACEUTICAZL CO., LTD. (KR) 1998-07-14 US disclosed
WO-1996021648-A1 NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1996-07-18 WO disclosed