Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | CTSK | P43235 | 10/20 | 0.57 |
| ▸ | CTSS | P25774 | 8/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8699255 | 1.00 | HDAC8 (0.59) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL23188882 | 1.00 | HDAC8 (0.59) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL3763472 | 0.89 | HDAC4 (0.61) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL8235050 | 0.89 | HDAC8 (0.53) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL21024477 | 0.89 | HDAC8 (0.59) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL26436622 | 0.87 | HDAC4 (0.65) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL23454631 | 0.87 | HDAC4 (0.65) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL10163667 | 0.87 | RXFP1 (0.52) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL19576327 | 0.86 | HDAC8 (0.49) | HDAC8HDAC4HDAC1CTSKCTSS | |
| SCHEMBL9609480 | 0.86 | CTSK (0.59) | HDAC8HDAC4HDAC1CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0669830-A4 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0669830-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994011012-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | disclosed |